Dynamics of Biochemical and Cytological Parameters of Rat Blood in Simulated Chronic Alimentary Methionine-Induced Homocysteinemia

Under the conditions of a chronic methionine diet (daily addition amino acids to food (0.15 g/100 g) and water (1% solution)) during 2–12 weeks, dynamics liver tests, infl ammatory changes in blood lipids was monitored. It found that (MD) leads, starting from 4 weeks MD, medium hyperhomocysteinemia, an increase enzymes (AsAT – 1.73, AlAT 1.5 times, p<0.05) bilirubin (by 62.25%), which indicates formed hepatopathy. Further (12 MD), condition is aggravated by abnormality excretory function development cholestasis (an alkaline phosphatase 1.65, 3.31 p<0.05).